WebDescription: Tegatrabetan, also known as Tegavivint and BC2059, is an orally bioavailable and potent β-catenin inhibitor. BC2059 potently induces apoptosis as a single agent and … WebTegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1).

NCB-0846 CAS 1792999-26-8 AbMole BioScience NCB-0846 …

WebTegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1). Stability and Solubility Advice: … WebTegatrabetan is an orally bioavailable and potent β-catenin inhibitor. BC2059 potently induces apoptosis as a single agent and in combination with bortezomib in multiple … sushi spinnery wiki

Tegatrabetan CAS:1227637-23-1 Probechem Biochemicals

WebJan 12, 2024 · For research use only. We do not sell to patients. Tegatrabetan. CAS No. : 1227637-23-1. Biological Activity：Tegatrabetan (BC2059) is a β-Catenin antagonist.Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1). WebIn vitro, tegatrabetan directly stimulates β-catenin degradation. In culture, tegatrabetan induces the apoptosis of desmoid tumor cells. A phase I/II trial is planned. The gamma-secretase inhibitor PF-03084014 stimulates the Notch pathway, which interacts with and indirectly regulates the Wnt/APC/β-catenin pathway. Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) [1] . Tegatrabetan (BC2059; 20-100 nM; 48 hours) inhibits cell proliferation in suspension culture over 120 hours and induces apoptosis of cultured human acute myeloid leukemia (AML) HL-60, OCI ... sushi spicy