Small vcp/p97-interacting protein expression

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August undefined, 2024

Web@article{Akcan2024AnalysisOT, title={Analysis of the developmental expression of small VCP-interacting protein and its interaction with steroidogenic acute regulatory protein in Leydig cells.}, author={G{\"u}lben Akcan and Ebru Alimoğullari and Radwan Abu-Issa and Sevil Cayli}, journal={Reproductive biology}, year={2024} } Gülben ... WebMar 6, 2024 · Background: Endoplasmic reticulum-associated protein degradation (ERAD) eliminates misfolded proteins. Numerous illnesses, including cancer, cystic fibrosis, diabetes, and neurological diseases, are influenced by ERAD. ... Investigation of the effects of small VCP-interacting protein (SVIP) on the migration and invasion of breast cancer …

Entry - *611745 - VCP/p47 COMPLEX-INTERACTING PROTEIN 1; …

Web1. Protein Expression and Purification: Executed protein purification with affinity, and size exclusion chromatography using AKTA workstations. WebAug 7, 2024 · Small VCP-interacting protein SVIP is an adaptor ER protein that can link directly to p97/VCP . SVIP is localized on the cytosolic surface of the ER membrane and … images of texas deed upon death

Valosin-containing protein - Wikipedia

WebProtein names Recommended name Small VCP/p97-interacting protein Gene names Name SVIP Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI … WebTsujimoto Y, Tomita Y, Hoshida Y, et al. Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer. Clin Cancer Res. 2004;10(9):3007–3012. 18. Cui Y, Niu M, Zhang X, Zhong Z, Wang J, Pang D. High expression of valosin-containing protein predicts poor prognosis in patients with breast … WebMar 9, 2024 · small VCP/p97-interacting protein GeneRIFs: Gene References Into Functions SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan. Overexpression of SVIP can protect HepG2 cells from the toxicity of CCl4, which could be enhanced by starvation. list of business ideas and problems to solve

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SVIP induces localization of p97/VCP to the plasma and …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebValosin-containing protein ( VCP) or transitional endoplasmic reticulum ATPase ( TER ATPase) also known as p97 in mammals and CDC48 in S. cerevisiae, is an enzyme that in humans is encoded by the VCP gene. [5] … images of texas chainsaw massacreWebHere we find that compounds that activate the D1 ATPase activity of VCP/p97 fulfill these requirements. Such effects are seen with small molecule VCP activators like SMER28, which activate autophagosome biogenesis by enhancing interactions of PI3K complex components to increase PI(3)P production, and also accelerate VCP-dependent … images of texas license plate

"WebUsing substrate trapping in vitro and in vivo in the human Ewing sarcoma TC32 cell line, they identified valosin-containing protein (VCP/p97) as a new PTPN13 substrate. As VCP/p97 phosphorylation is necessary for PTPN13 midbody localization during cell division, a PTPN13 pro-oncogenic role in Ewing sarcoma, mediated through regulation of cell ... " - Small vcp/p97-interacting protein expression

Small vcp/p97-interacting protein expression

WebJan 18, 2024 · VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. The AAA+-type ATPase p97 governs an ever-expanding number of cellular … WebJul 12, 2024 · possesses therapeutic potential. For example, valosin-containing protein (VCP/p97) is a hub protein that interacts with more than 30 adaptor proteins involved in various cellular functions. However, the role of each p97 PPI during the relevant cellular event is underexplored. The development of small-molecule PPI modulators remains …

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WebSmall p97/VCP-interacting protein (SVIP) was first discovered as one of the novel androgen-responsive genes as well as one of the many cofactors controlling p97/VCP. The aim of … WebApr 11, 2024 · The mRNA expression levels of HRD1, gp78, E3 ligase enzymes; p97/VCP, retrotranslocation protein; UFD1L and NPL4, cofactor proteins; OS9, ER lectin protein and UFD2A which functions as ubiquitin-chain elongation factor E3/E4 ubiquitin ligase were significantly up-regulated by dexamethasone induction in a dose-dependent manner (Fig. …

WebY. Amagasaki is an academic researcher. The author has contributed to research in topic(s): Precipitin & Antigen. The author has an hindex of 1, co-authored 1 publication(s) receiving 10 citation(s). WebJan 18, 2024 · p97/VCP (CDC48p in yeast) is a highly abundant molecular chaperone that functions in diverse cellular processes such as ubiquitin-dependent proteolysis, retrograde transport of protein from...

WebDec 2, 2024 · The funnel is itself a protein named VCP/p97, which can draw in other proteins via its central pore. It plays a major role in the cell’s own quality control: in case a protein … WebSVIP → Small VCP/p97-interacting protein Gene name : SVIP Family name : SVIP Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. INTERACTIONS Interacts (via VIM motif) with VCP. • gold 1 ev UniProt GO MOLECULAR …

WebMicroinjection of antibodies against Vcip135 and p47 in rat kidney cells showed that Vcip135 and p47 were required for Golgi and endoplasmic reticulum assembly. Wang et al. (2004) found that p97/p47-mediated reassembly of Golgi cisternae required ubiquitin. They identified rat Vcip135 as a deubiquitinating enzyme and found that it reversed the ...

WebJan 28, 2024 · The essential protein VCP/p97 regulates autophagosome formation by promoting the deubiquitinase activity of ataxin-3 toward Beclin-1 and also by regulating the assembly of the Beclin-1–PI3K ... list of business expenses pdfWeb(A) Protein groups identified from single motor neurons (MNs) and interneurons (INs). (B) Venn diagram indicating overlap of identified protein groups. (C) Principle component … list of business ideas for beginners in indiaWebGeldanamycin and Velcade, new anticancer drugs with novel mechanisms of action, are currently undergoing extensive clinical trials. Geldanamycin interrupts Hsp90 chaperone activity and causes down-re list of business for saleWebAug 31, 2011 · The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in HeLa cells leads to localization of p97/VCP at the plasma membrane, intracellular foci and juxtanuclear vacuoles. list of business industriesWebAug 31, 2011 · The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in... images of textron secatWebMar 1, 2024 · Small p97/VCP-interacting protein (SVIP) is an interacting cofactor that regulates the p97/valosin containing protein (VCP), an AAA + ATPase involved in the … images of texas windmillsWebVCP stimulates the deubiquitinase activity of ATXN3 (ataxin 3) to stabilize BECN1 protein levels and also interacts with and promotes the assembly and kinase activity of the … images of texas snakes