WebBMC Bioinformatics (May 2011) . PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality The performances of PoPMuSiC in predicting the changes in folding free energy resulting from single-site mutations were evaluated using a 5-fold cross validation procedure [29]. In a first step, the values of the parameters of the αi(A) functions (eq. (3)) were identified so as to minimize the root mean square error … See more In addition to its high level of performances, and in particular its good specificity to stabilizing mutations, the ability of the PoPMuSiC-2.1 server to rapidly … See more To illustrate the relevance and usefulness of the sequence optimality scores Γ computed by PoPMuSiC-2.1, we investigated the relationship between the … See more
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WebFuture breakthroughs in medical research may also be expected from an improved understanding of the effect of naturally occurring disease-causing mutations on the … WebAug 3, 2009 · The PoPMuSiC program (Gilis and Rooman, 2000; Kwasigroch et al., 2002) was the first to be general enough for predicting stability changes caused by mutations at … great clips menomonie wi