Phospho-s6
WebDec 21, 2024 · Abstract Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been recognized as a surrogate marker for the activated PI3K/AKT/mTORC1 pathway, which occurs in many cancer types. WebApr 27, 2024 · As previously reported, loss of PTEN led to enhanced phosphorylation of AKT and its downstream target, S6 kinase, ... D Immunoblot of (phospho-)AKT and (phospho-)S6 BEAS-2B wildtype (WT), PTEN homo, BRAF V600E and compound mutant cell lines without and with 2 µM PI-103 pre-treatment for 3 h. DMSO as solvent control.
Phospho-s6
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Web7/2/2024 Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb (Alexa Fluor® 488 Conjugate) (#4854) Datasheet Witho… WebApr 15, 2014 · The series included 6 normal bladder urothelial samples and 129 UC (Ta n = 25, T1 n = 34, T2-T3-T4 n = 70). Expression of phospho-AKT (pAKT), phospho-S6-Ribosomal Protein (pS6) (one downstream effector of PI3K/AKT pathway) and PTEN was evaluated by reverse phase protein Array.
WebMonoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser235 and Ser236 of human ribosomal protein … WebApr 13, 2024 · Figure 3.Proteomic and phospho-proteomic analysis of Obscn-ΔIg58/59 atria at 6-months.(A,A’) Volcano plots of significantly up-regulated (green) or down-regulated (red) proteins (A) and significantly altered phospho-peptides (blue; A’) in Obscn-ΔIg58/59 atria at 6-months. A total of 45 proteins out of 1700 detected exhibited significantly altered …
WebGeneral description. S6 kinase (p70s6k) is activated by an upstream kinase, mTOR in response to nutrients and growth factors. [ 1] [ 2] S6 kinase (p70s6k) is a critical regulatory component and mTOR along with the eukaryotic initiation factor 4E (eIF4E)–binding protein 1 (4E-BP1) and S6 kinase (p70s6k) leads to increased ribosomal biogenesis ... WebThe Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway. P70S6K plays a crucial …
WebDec 21, 2012 · No effects were observed on the levels of phospho-S727 STAT3, phospho-Erk1/2, or phospho-S6, which are not catalyzed by JAK2, thus confirming the specificity of both drugs for JAK2/STAT3 and lack of significant off-target effects on …
WebIHC. Western blot analysis of NIH/3T3, using Phospho-mTOR-S2448 Rabbit mAb (AP1413) at 1:1000 dilution.NIH/3T3 cells were treated by EGF (100 ng/ml) at 37℃ for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat ... how to remove dcfwinserviceWeb核糖体S6蛋白激酶β2抗体 P70 Beta 2抗体现货 抗体,(免疫球蛋白不仅仅只是抗体)是一种由B淋巴细胞分泌,被免疫系统用来鉴别与中和外来物质如细菌、病毒等的大型Y形蛋白质,仅被发现存在于脊椎动物的血液等体液中,及其B细胞的细胞膜表面。 how to remove dbutilWebThis gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. how to remove ddq from reactionWebJul 2, 2015 · Treatment with the proteasome inhibitor bortezomib restored phospho-S6 levels, suggesting that the reduction of phospho-S6 is caused by increased degradation of phospho-S6, but not total S6. Surprisingly, treatment with other autophagy inhibitors did not exhibit the same effects. Our findings suggest that HCQ causes the down-regulation of ... how to removed by default widget in zerif proWebA Phospho-S6 Ribosomal Protein (Ser235/236) Antibody has been coated onto the microwells. After incubation with cell lysates, only phospho-S6 ribosomal protein is … how to remove dch driversWebMar 22, 2024 · Ribosomal protein S6 is one of the components of the 40 S ribosomal subunit . Previous study found that rpS6 underwent phosphorylation during rat liver regeneration [ 14 ]. In mammalian cells, the phosphorylation sites of rpS6 have been mapped to five clustered serine residues, Ser 235 , Ser 236 , Ser 240 , Ser 244 , and Ser 247 , which … how to remove dbrand skin from laptopWebPhospho-S6 Ribosomal Protein (Ser235/236) Antibody detects endogenous levels of ribosomal protein S6 only when phosphorylated at serine 235 … how to remove dch drivers nicehash