Kif3b crmp2

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August undefined, 2024

WebWe biochemically identified CRMP2 as a cargo of the KIF3 motor and simultaneously as a carbonylation-sensitive actin bundling factor and thus hypothesized that betaine-induced … WebAccording to a deficiency in the transport of collapsin response mediator protein 2 (CRMP2) by the KIF3 motor, we identified a significant reduction in lamellipodial dynamics in …

FAB: Yoshihara S et al 2024 - Betaine ameliorates schizophrenic …

Web10 nov. 2024 · Here, we demonstrate that 194 (i) specifically inhibits the CRMP2-Ubc9 interaction and SUMOylation of CRMP2, (ii) decreases NaV1.7 currents in sensory neurons from four species, (iii) reduces … Web(CRMP2) by the KIF3 motor, we identiﬁed a signiﬁcant reduction in lamellipodial dynamics in developing Kif3b+/ neurons as a cause of neurite hyperbranching. Betaine … phil crocket wakefield ma

KIF3B Gene - GeneCards KIF3B Protein KIF3B Antibody

Web25 jun. 2024 · We identified significant reduction and restoration by betaine of lamellipodial dynamics in developing Kif3b+/- neurons as a cause of neurite hyperbranching, … Web25 okt. 2024 · The team had previously identified the neuronal regulator protein, collapsin response mediator protein 2 (CRMP2), as a major target of carbonylation in the brain (M. … Web3 jun. 2024 · The C-terminal domain of CRMP2 binds to the TPR domains of KLC1 and transports the Sra-1/WAVE1 complex during axon formation (Kawano et al., 2005). ... Loss of Kif3B and TRIM46 altered the microtubule polarity in the AIS in tissue-cultured cells (Ichinose et al., 2024; Van Beuningen et al., ... phil crocker

Betaine ameliorates schizophrenic traits by functionally ... - Cell

Selective targeting of NaV1.7 via inhibition of the …

WebThe kif3b gene belongs to what's known as a kinesin superfamily of genes. These genes play an important role in mammals by encoding for motor proteins that work together to … WebThese data, combined with previous data from other labs, indicate that KIF3C and KIF3B are "variable" subunits that associate with a common KIF3A subunit, but not with each other . Additional immunoprecipitation studies revealed the association of RPGR-ORF15 isoform(s) with the intraflagellar transport polypeptide IFT88 as well as microtubule motor … phil cricketer question of sportWeb20 apr. 2024 · Chemical analyses of the brains of kif3b mutant mice and human schizophrenia patients reveal significant chemical damage to CRMP2, which causes the … phil crockett you tube

"Web21 apr. 2024 · A chemical analysis of the brains of kif3b mutant mice and human schizophrenia patients revealed damage to CRMP2, a protein used for the assembly of actin. As such, the researchers proposed that betaine may help patients with schizophrenia by preventing a kind of chemical damage, known as carbonyl stress, that leads to … " - Kif3b crmp2

Kif3b crmp2

Betaine ameliorates schizophrenic traits by functionally …

Web13 apr. 2024 · According to a deficiency in the transport of collapsin response mediator protein 2 (CRMP2) by the KIF3 motor, we identified a significant reduction in … WebWe have also identified CRMP2 as a cargo of KIF3 motor using a mass-spectroscopy-based analysis. According to this information, we synthesized pellets of high-betaine diet (HBD) …

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Web13 apr. 2024 · We biochemically identified CRMP2 as a cargo of the KIF3 motor and simultaneously as a carbonylation-sensitive actin bundling factor and thus hypothesized … WebOverexpression of CRMP2 significantly inhibits invasion and stemness in breast cancer cells, while downregulation of CRMP2 promotes cell invasion, which is not required for tubulin polymerization. Mechanistic studies demonstrate that CRMP2 interacts with RECK, prevents RECK degradation, which, in turn, blocks NF-κB and Wnt signaling pathways.

Web5 sep. 2024 · KIF3A and KIF3B are homologous motor subunits of the Kinesin II protein family. KIF3A, KIF3B, and KAP3 form a heterotrimeric complex and play a significant role in spermatogenesis. Here, we first cloned full-length kif3a/3b cDNAs from Larimichthys polyactis. Lp-kif3a/3b are highly related to their homologs in other animals. The proteins … WebBackground. Collapsin Response Mediator Protein-2 (CRMP-2) is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule ...

WebCollapsin response mediator protein 2 (CRMP2) has long been identified as a microtubule-binding protein that regulates neuronal polarity in vitro. Recent studies provide new insights into the roles of CRMP2 in neuronal migration and subsequent neuronal differentiation. Web11 apr. 2024 · Background and PurposeAn increasing number of autoimmune encephalitis (AE)-associated autoantibodies have been successfully characterized. However, many cases of AE remain unexplained on account of unknown antibodies. The aim of the present study was to identify a novel antibody against collapsin response mediator protein 2 …

WebAccording to a deficiency in the transport of collapsin response mediator protein 2 (CRMP2) by the KIF3 motor, we identified a significant reduction in lamellipodial dynamics in …

Web19 apr. 2024 · Chemical analyses of the brains of kif3b mutant mice and human schizophrenia patients reveal significant chemical damage to CRMP2, which causes the … phil crombieWebThe transport of N‐methyl‐d‐aspartate receptors (NMDARs) is crucial for neuronal plasticity and synapse formation. Here, we show that KIF3B, a member of the kinesin superfamily proteins (KIFs), supports the transport of vesicles simultaneously containing NMDAR subunit 2A (NR2A) and the adenomatous polyposis coli (APC) complex. phil crockett thomasWeb10 okt. 2024 · KIF3B is essential for differential Shh protein behavior underlying its gradient formation (A–D) z- projection images of whole-mount Shh immunohistochemistry of forelimb buds with the 5E1 antibody (A and B) with statistics of peripheral intensity (D) in a polar coordinate system (C). Scale bar, 100 μm. ∗∗∗ p < 0.001, two-way ANOVA, n = 5. phil croll