Webof HTLV-1-infected T-cell lines. T cells cultured with butein showed obvious apoptosis morphology, and cleavage of poly(ADP-ribose) polymerase with activation of caspase-3, -8 and -9. Pretreatment of cells with caspase inhibitor partially blocked butein-induced inhibition of cell viability. Butein also resulted in cell cycle arrest at G 1 phase. WebIn ovarian cancer, butein inhibited cell proliferation, migration, and invasion, and induced cell cycle arrest and apoptosis, and decreased the growth of ovarian cancer cells in xenograft tumor models. Butea monosperma (Fabaceae) has been used in traditional Indian medicine to treat a variety of ailments, including abdominal tumors. We aimed to …
Butein induces G2 - ScienceDirect
WebNov 27, 2024 · Butein (3,4,2′,4′-tetrahydroxychalcone) inhibited inhibitor of nuclear factor kappa-B kinase subunit beta ... and 2′-hydroxy-2,4,6-trimethoxy-5′,6′-naphthochalcone induced G2/M cell cycle arrest and apoptosis . An anticancer effect was common among these chalcones. The α,β-unsaturated carbonyl group in chalcones acted as a Michael ... WebDec 10, 2015 · Additionally, butein mediated cell cycle arrest in S-phase. Therefore, the butein-activated p53 pathway may arrest cells at S-phase, resulting in apoptotic cell death. The present study further demonstrated that butein reduced the protein expression of MDM2 in both p53-expressing KBM5 and p53-null K562 cells, while butein increased the … convert power apps portal to production
Butein Promotes Lineage Commitment of Bone Marrow-Derived …
WebMar 23, 2024 · Butein Induced Ovarian Cancer Cell Cycle Arrest and Cell Apoptosis. Cell cycle progression was monitored using flow cytometry. Exposure to butein resulted in … WebButein. Butein (20, 40, 3, 4-tetrahydroxychalcone), is a chalcone that has exhibited a wide range of pharmacological effects such as antiinflammatory, anticancer, antioxidant, and … Web4、tin.2 2) FoxO3a and its downstream molecules play a role in the synergistic effects of butein and cisplatin.23) Butein suppresses cell proliferation and enhances apoptosis in … convert powerapps form to pdf